Looking for this week’s NFL picks? Below you’ll find our National Football League predictions, including moneyline picks, against-the-spread picks, totals, our best bet of the week, and game-by-game analysis. We update this page throughout the NFL preseason, regular season, and playoffs while tracking our running betting record.
NFL Week 6 Picks and Predictions
The NFL Week 6 schedule begins with Seattle visiting Denver on Thursday night. Sunday features another London game, three divisional matchups, a meeting between undefeated Kansas City and winless Los Angeles, and a high-scoring Sunday night possibility between Dallas and Green Bay.
Our Week 6 card includes moneyline, point-spread, and over/under predictions for all 14 games. The Cincinnati Bengals, Detroit Lions, Miami Dolphins, and Minnesota Vikings are on bye. Bettors can also visit Sports Game Picks for additional free NFL picks throughout the season.
Betting lines used for these predictions were available on October 14, 2026, and may move before kickoff.
NFL Week 6 Picks Table
| Game | Moneyline Pick | ATS Pick | Total Pick | Best Bet |
|---|---|---|---|---|
| Seahawks at Broncos | Seahawks | Seahawks -2.5 | Over 40.5 | — |
| Texans vs. Jaguars | Jaguars | Jaguars -2.5 | Under 42.5 | — |
| Saints at Giants | Giants | Giants +1.5 | Under 45.5 | — |
| Jets at Patriots | Patriots | Patriots -7 | Under 43.5 | — |
| Bears at Falcons | Falcons | Falcons +3 | Over 49.5 | — |
| Steelers at Buccaneers | Steelers | Steelers -2.5 | Under 39.5 | — |
| Titans at Colts | Colts | Colts -7 | Under 44 | Colts -7 |
| Ravens at Browns | Ravens | Ravens -4.5 | Under 41.5 | — |
| Panthers at Eagles | Panthers | Panthers +1.5 | Under 40.5 | — |
| Cardinals at Rams | Rams | Cardinals +12.5 | Over 52.5 | — |
| Bills at Raiders | Bills | Bills -5 | Over 53.5 | — |
| Chargers at Chiefs | Chiefs | Chiefs -8 | Under 42.5 | — |
| Cowboys at Packers | Packers | Packers -1.5 | Under 52.5 | — |
| Commanders at 49ers | 49ers | Commanders +7.5 | Over 50.5 | — |
NFL Week 6 Slate Overview
Week 6 presents a fascinating mix of small spreads, large favorites, and injury-driven market movement. Jacksonville opened as an underdog against Houston but is now favored in London. Kansas City moved from a small favorite to more than a touchdown against the Chargers, while the Pittsburgh–Tampa Bay total dropped into the 30s.
The best underdog opportunities come from the Giants, Falcons, Panthers, Cardinals, and Commanders. New York, Atlanta, and Carolina are also live moneyline underdogs. Arizona and Washington face more difficult straight-up assignments, but their double-digit or near-double-digit spreads create room for competitive losses.
Indianapolis provides the clearest favorite to back against the spread. Tennessee is 0-5, ranks last in scoring and total offense, and managed only three points against Houston. The Colts have defensive weaknesses, but the Titans have not shown that they can exploit them.
NFL Best Bet of Week
Best Bet: Indianapolis Colts -7 over Tennessee Titans
Tennessee enters Week 6 averaging only 11.6 points and 246.4 total yards per game. Both figures rank last in the NFL. The Titans are coming off a 26-3 loss to Houston in which they finished with only 187 total yards and allowed Cam Ward to be sacked four times.
Indianapolis struggled to finish drives in its 34-22 loss to Pittsburgh, but the Colts still scored on six of their nine meaningful possessions. Returning to Lucas Oil Stadium against Tennessee should provide Daniel Jones, Jonathan Taylor, and the Indianapolis offense with a much easier matchup.
The Colts do not need a flawless defensive performance to cover. If Indianapolis reaches the mid-20s, Tennessee will likely need its best offensive showing of the season to remain inside the number.
Be sure to check out our full Titans vs Colts Prediction.
Predicted Score: Colts 27, Titans 10
Seattle Seahawks at Denver Broncos
Seattle suffered its second loss of the season when San Francisco escaped with a 32-29 victory. The Seahawks still average 26.8 points per game and should find opportunities against a Denver secondary dealing with injuries to Patrick Surtain II and Talanoa Hufanga.
Denver defeated the Chargers 23-17 despite producing only 224 total yards. The Broncos have remained competitive through defense and field position, but they will need more offensive production against Seattle. The Seahawks have enough playmakers to win and cover a short road spread.
Predicted Score: Seahawks 24, Broncos 20
Picks: Seahawks moneyline, Seahawks -2.5, and over 40.5
Houston Texans vs. Jacksonville Jaguars
Houston earned its first victory by holding Tennessee to three points. The defensive improvement was encouraging, but Jacksonville presents a far more difficult challenge after winning four of its first five games.
The Jaguars remained in England following their 19-17 victory over Philadelphia, eliminating another long trip before this game at Wembley Stadium. Jacksonville lost starting left tackle Anton Harrison to a knee injury, but its defense and familiarity with London still provide meaningful advantages.
Predicted Score: Jaguars 23, Texans 17
Picks: Jaguars moneyline, Jaguars -2.5, and under 42.5
New Orleans Saints at New York Giants
New Orleans was held to 142 total yards in a 23-13 loss to Minnesota. Tyler Shough threw for only 96 yards and was intercepted twice against the Vikings’ aggressive defense.
The Giants played Washington to a 27-27 tie and enter Week 6 with only one loss. New York has the stronger recent form and is playing at home, making the Giants attractive as a small underdog. Neither offense can be trusted enough to support a high-scoring prediction.
Predicted Score: Giants 23, Saints 20
Picks: Giants moneyline, Giants +1.5, and under 45.5
New York Jets at New England Patriots
The Jets improved to 2-3 by defeating Cleveland 17-12. Their defense recorded eight sacks, but the offense still struggled to create consistent scoring opportunities.
New England followed its upset of Buffalo with a 45-17 demolition of Las Vegas. Drake Maye threw for 374 yards and four touchdowns as the Patriots accumulated 536 total yards. New England should control this matchup, although its growing injury list makes laying more than a touchdown uncomfortable.
Predicted Score: Patriots 27, Jets 16
Picks: Patriots moneyline, Patriots -7, and under 43.5
Chicago Bears at Atlanta Falcons
Chicago’s three-game winning streak ended with a 31-7 loss at Green Bay. The Bears committed five turnovers and received little production from Tyson Bagent before Case Keenum entered the game.
Caleb Williams is moving closer to returning from his hamstring injury, but his availability remains important. Atlanta pushed Baltimore to overtime and has scored at least 23 points in three consecutive games. The Falcons’ rushing attack and home-field advantage make them the more attractive side as an underdog.
Predicted Score: Falcons 27, Bears 24
Picks: Falcons moneyline, Falcons +3, and over 49.5
Pittsburgh Steelers at Tampa Bay Buccaneers
Pittsburgh improved to 3-2 after Aaron Rodgers threw three touchdown passes in a 34-22 victory over Indianapolis. The Steelers have scored at least 30 points in three consecutive games, but this total has dropped sharply because of Tampa Bay’s quarterback situation.
The Buccaneers earned their first win by upsetting Dallas 24-16. Tampa Bay’s defense should keep the game competitive, but the Steelers have the more reliable quarterback and a defense capable of pressuring an inexperienced passer.
Predicted Score: Steelers 23, Buccaneers 13
Picks: Steelers moneyline, Steelers -2.5, and under 39.5
Tennessee Titans at Indianapolis Colts
Tennessee remains winless after being held to three points and 187 total yards by Houston. The Titans average a league-low 11.6 points and 246.4 yards per game, leaving very little margin for defensive mistakes.
Indianapolis settled for five field goals against Pittsburgh and must improve inside the red zone. Even so, the Colts average 24.8 points per game and have significantly more offensive talent. Jonathan Taylor should receive a heavy workload as Indianapolis attempts to control the game and protect its defense.
Predicted Score: Colts 27, Titans 10
Picks: Colts moneyline, Colts -7, and under 44
Baltimore Ravens at Cleveland Browns
Baltimore improved to 4-1 after overcoming a late deficit to defeat Atlanta 30-23 in overtime. Tyler Huntley led the tying drive and scored the winning touchdown after replacing the injured Lamar Jackson.
Cleveland allowed eight sacks in its 17-12 loss to the Jets. The Browns should keep the game competitive through defense, but their offensive-line problems create a dangerous matchup against Baltimore’s pressure packages. Jackson’s availability should still be monitored before placing a wager.
Predicted Score: Ravens 24, Browns 16
Picks: Ravens moneyline, Ravens -4.5, and under 41.5
Carolina Panthers at Philadelphia Eagles
Carolina returns from its bye after defeating Detroit 32-26 in Week 4. Bryce Young threw for 329 yards in that victory, while the Panthers rushed for 186 yards and controlled the game against an explosive opponent.
Philadelphia has lost three consecutive games and produced only 232 yards in its 19-17 loss to Jacksonville. The Eagles are also dealing with injuries at running back, wide receiver, and along the defensive front. Carolina has a legitimate opportunity to win outright against a struggling favorite returning from London.
Predicted Score: Panthers 21, Eagles 17
Picks: Panthers moneyline, Panthers +1.5, and under 40.5
Arizona Cardinals at Los Angeles Rams
Arizona has lost four consecutive games after surrendering 45 points to Detroit. The Cardinals allowed 151 rushing yards to Jahmyr Gibbs and could have similar problems against the Rams’ balanced offense.
Los Angeles returns home after losing 37-34 in overtime to Buffalo on Monday night. The Rams should win, but playing on a short week after an emotional overtime game makes laying 12.5 points risky. Arizona can produce enough late scoring to remain inside the spread and help push the game over the total.
Predicted Score: Rams 31, Cardinals 23
Picks: Rams moneyline, Cardinals +12.5, and over 52.5
Buffalo Bills at Las Vegas Raiders
Buffalo rebounded from its first loss by defeating the Rams 37-34 in overtime. Josh Allen produced 331 total yards, while the Bills rushed for 234 yards and three touchdowns.
Las Vegas was overwhelmed 45-17 by New England and allowed 536 total yards. Returning home should help, but the Raiders must show that their defense can prevent another elite quarterback from controlling the game. Buffalo should pull away once Las Vegas is forced into a pass-heavy comeback attempt.
Predicted Score: Bills 31, Raiders 24
Picks: Bills moneyline, Bills -5, and over 53.5
Los Angeles Chargers at Kansas City Chiefs
The Chargers fell to 0-5 after allowing Denver to score 13 unanswered fourth-quarter points. Los Angeles managed only 224 total yards and has now scored 17 points or fewer in four of its five games.
Kansas City returns from its bye as the AFC’s only undefeated team. The Chiefs have scored at least 30 points in three of their four games and should benefit from the extra preparation time. Los Angeles may keep the game close early, but Kansas City’s defense and quarterback advantage should eventually create separation.
Predicted Score: Chiefs 27, Chargers 13
Picks: Chiefs moneyline, Chiefs -8, and under 42.5
Dallas Cowboys at Green Bay Packers
Dallas suffered a disappointing 24-16 home loss to previously winless Tampa Bay. The Cowboys have surrendered at least 24 points in four consecutive games and have struggled to protect the football in important situations.
Green Bay forced five turnovers in its 31-7 victory over Chicago. Jordan Love threw for 367 yards and two touchdowns as the Packers produced their most complete performance of the season. Green Bay should win at home, but the total is high enough to favor the under.
Predicted Score: Packers 28, Cowboys 23
Picks: Packers moneyline, Packers -1.5, and under 52.5
Washington Commanders at San Francisco 49ers
Washington received 302 total yards and two rushing touchdowns from Jayden Daniels in his return, but the Commanders settled for a 27-27 tie against the Giants. Daniels makes the offense substantially more dangerous than it was during his absence.
San Francisco remained undefeated by beating Seattle 32-29. The 49ers forced four turnovers and converted them into 21 points, but an injury to Deebo Samuel adds another concern to an already tested roster. San Francisco should win at home, although Washington’s quarterback gives the Commanders enough scoring ability to cover.
Predicted Score: 49ers 28, Commanders 24
Picks: 49ers moneyline, Commanders +7.5, and over 50.5
NFL Picks Record Regular Season
| Category | Record |
|---|---|
| Overall NFL Picks | 95-97 |
| Moneyline Picks | 46-32-1 |
| ATS Picks | 30-49 |
| Total Picks | 47-32 |
| Best Bets | 2-3 |
The regular-season record begins at 0-0 and will be updated after the completion of Week 1.
NFL Preseason Picks Record
| Category | Record |
|---|---|
| Overall NFL Picks | 32-18-1 |
| Moneyline Picks | 9-8-0 |
| ATS Picks | 8-8-1 |
| Total Picks | 15-2-0 |
| Best Bets | 0-2 |
The record will begin with the 2026 NFL preseason and will be updated after each completed slate.It will be updated to regular season picks only after the preseason is completed.
How to Bet on NFL Games
The three most popular NFL betting markets are the moneyline, point spread, and game total. Each market provides a different way to wager on a game depending on where you believe the best betting value exists.
A moneyline wager is a bet on which team will win the game outright. The final margin does not matter. Favorites normally come with a higher price, while an underdog moneyline offers a larger potential return.
ATS stands for “against the spread.” The favorite must win by more than the listed point spread to cover, while the underdog can cover by winning outright or losing by fewer points than the spread. If the final margin lands directly on the listed number, the wager is normally graded as a push.
A total wager focuses on the combined number of points scored by both teams. Bettors can select the over if they expect the teams to combine for more points than the posted total or the under if they anticipate a lower-scoring contest.
What We Consider When Making NFL Picks
Our NFL picks are focused on identifying betting value rather than simply selecting the most recognizable team or obvious favorite. We evaluate quarterback play, offensive and defensive efficiency, recent performance, turnover margin, injuries, home-field advantage, scheduling situations, coaching tendencies, weather conditions, and how sportsbooks are pricing each matchup.
During the preseason, we place additional importance on quarterback rotations, projected playing time, roster depth, coaching approach, and the number of established starters expected to participate. Preseason results are less predictable because winning the game is not always a team’s primary objective.
The process changes during the playoffs, when teams shorten their rotations and every possession carries greater importance. Regardless of the point in the season, the goal remains the same: finding a wager where the available odds may not fully reflect the most likely outcome.
NFL Betting Tips
Shopping for the best available line is one of the simplest ways to improve your long-term NFL betting results. A half-point difference may not appear significant, but it can determine whether a point-spread or total wager wins, loses, or pushes.
It is also important to distinguish between predicting a winner and identifying betting value. A team may be likely to win without offering value at its current moneyline or point spread. Likewise, an underdog can be a worthwhile wager even when it is not expected to win outright.
Remain disciplined with your wager sizes and avoid dramatically increasing your stakes after a loss. Successful sports betting is based on making consistent decisions over an entire season rather than trying to win every wager.
NFL Preseason Betting
NFL preseason games require a different approach from regular-season contests. Star players may appear for only a few drives or remain on the sideline for the entire game. Backup quarterbacks, rookies, and players competing for roster spots can determine the final result.
Coaches also have different preseason priorities. Some place greater emphasis on winning, while others focus almost exclusively on player evaluation and installing their systems. Projected quarterback rotations and roster depth can therefore be more useful than a team’s previous regular-season record.
Betting lines may move quickly when information about playing time becomes public. Waiting for reliable reports can provide valuable information, although it may also mean accepting a less favourable number.
NFL Regular-Season Betting
Regular-season NFL betting offers more dependable information about team strength, personnel, coaching tendencies, and player roles. However, bettors should avoid reacting too strongly to one result, particularly during the opening weeks.
Matchups are often more important than overall records. A strong team may encounter difficulties against an opponent whose defensive scheme or offensive style exposes a specific weakness. Travel, rest, weather, injuries, and changes along the offensive line can also influence the betting value.
Because NFL point spreads and totals move throughout the week, the number attached to a wager is just as important as the team being selected.
NFL Playoff Betting
The NFL playoffs feature stronger competition and increased public betting interest. Sportsbooks have extensive information about every remaining team, which can make obvious value more difficult to find.
Home-field advantage, quarterback experience, defensive pressure, weather, and late-game execution become particularly important during elimination games. Bettors should also consider how each team’s style matches up against its opponent rather than relying solely on its regular-season record.
The Super Bowl presents an additional challenge because of the two-week break, neutral venue, increased media attention, and expanded selection of betting markets.
Responsible Gambling Reminder
Sports betting should always be treated as entertainment rather than guaranteed income. Only wager what you can comfortably afford to lose, establish reasonable limits, and never chase losses.
If betting stops being enjoyable or begins causing financial or emotional stress, take a break and seek assistance. Responsible gambling is more important than the outcome of any individual wager.
NFL Picks FAQ
Are these NFL picks updated every week?
Yes. We update this page throughout the NFL preseason, regular season, and playoffs with moneyline picks, ATS picks, total picks, and our best bet.
Do you provide picks for every NFL game?
Yes. Whenever a complete NFL slate is available, we aim to provide picks and analysis for every scheduled game.
What is the best NFL bet this week?
Our favourite wager is featured in the NFL Best Bet of the Week section near the top of the page. The selection may be a moneyline, point spread, total, or another widely available betting market.
Do you track your NFL betting record?
Yes. We maintain running records for our overall NFL picks, moneyline selections, ATS picks, totals, and best bets.
What does ATS mean in NFL betting?
ATS stands for “against the spread.” Instead of merely selecting the winner, you are wagering on whether a team will cover the point spread established by the sportsbook.
What does NFL moneyline mean?
An NFL moneyline wager is a bet on which team will win the game outright. The winning margin does not matter, but favourites and underdogs are offered at different prices.
What is an NFL total?
The total is the projected number of combined points for both teams. Bettors can wager on whether the final combined score will finish over or under that number.
Do you provide NFL preseason picks?
Yes. Our NFL coverage begins with the preseason and continues through the Super Bowl. Because preseason playing time can be unpredictable, we wait for reliable quarterback rotation and personnel information whenever possible.
When should I place an NFL bet?
That depends on the market. Betting early may help you secure a favourable line, while waiting can provide more information about injuries, weather, and projected player availability. Always compare the latest odds before placing a wager.
What is the best way to bet on NFL games?
Most NFL bettors focus on moneylines, point spreads, and totals. The key is identifying value, comparing odds, managing your bankroll, and remaining disciplined throughout the season.
More Free Football Picks
Are you looking for more predictions? Check out our free football picks covering the biggest games from across the sport.
Interested in Canadian football? Visit our free CFL picks for weekly moneyline, ATS, total, and best-bet predictions.
College football more your jam? Check out our free college football picks throughout the regular season, conference championships, and bowl schedule.
If you want to keep up with the latest news and trade rumors then check out the NFL website.
