Looking for this week’s NFL picks? Below you’ll find our National Football League predictions, including moneyline picks, against-the-spread picks, totals, our best bet of the week, and game-by-game analysis. We update this page throughout the NFL preseason, regular season, and playoffs while tracking our running betting record.
NFL Week 10 Picks and Predictions
The NFL Week 10 schedule runs from Thursday, November 12 through Monday, November 16, 2026. The slate begins with an NFC East matchup between the Washington Commanders and New York Giants before moving to Munich for an early Sunday game between the New England Patriots and Detroit Lions.
Sunday’s schedule also features Minnesota visiting Green Bay, Pittsburgh facing Cincinnati, San Francisco traveling to Dallas, and Jacksonville attempting to strengthen its AFC South lead against Tennessee. The week concludes with the Los Angeles Chargers visiting the Baltimore Ravens on Monday night.
Our NFL Week 10 card includes moneyline, point-spread, and over/under predictions for all 14 games. Bettors can also visit Sports Game Picks for additional free NFL picks throughout the season.
NFL Week 10 Picks Table
| Game | Moneyline Pick | ATS Pick | Total Pick | Best Bet |
|---|---|---|---|---|
| Commanders at Giants | Giants | Giants -2.5 | Under 41.5 | — |
| Patriots vs. Lions | Lions | Lions -2.5 | Over 51 | — |
| Chiefs at Falcons | Chiefs | Chiefs -3.5 | Over 45.5 | — |
| Texans at Browns | Texans | Texans -5 | Under 40 | — |
| Vikings at Packers | Packers | Packers -3.5 | Over 42 | — |
| Dolphins at Colts | Colts | Colts -3.5 | Under 38.5 | — |
| Panthers at Saints | Saints | Saints -2.5 | Over 48.5 | — |
| Bills at Jets | Bills | Bills -8 | Under 51 | — |
| Jaguars at Titans | Jaguars | Jaguars -10.5 | Under 46.5 | Jaguars -10.5 |
| Rams at Cardinals | Rams | Rams -9 | Under 39.5 | — |
| Seahawks at Raiders | Seahawks | Seahawks -6.5 | Over 40.5 | — |
| 49ers at Cowboys | 49ers | 49ers -4 | Over 55.5 | — |
| Steelers at Bengals | Bengals | Bengals -3.5 | Over 49.5 | — |
| Chargers at Ravens | Ravens | Ravens -4.5 | Under 38.5 | — |
NFL Week 10 Slate Overview
Four teams are off in Week 10: Chicago, Denver, Philadelphia, and Tampa Bay. The remaining schedule includes four divisional games and several matchups involving teams moving in opposite directions.
Jacksonville and Buffalo are the two largest favorites. The Jaguars are laying 10.5 points against Tennessee, while Buffalo is favored by eight against the Jets. Los Angeles–Arizona, Houston–Cleveland, and Miami–Indianapolis carry some of the lowest totals on the board.
San Francisco–Dallas owns the largest total at 55.5. The 49ers have one of the league’s most efficient offenses, while Dallas has scored 246 points but surrendered 236 through nine games. That combination creates the best shootout opportunity on the slate.
NFL Best Bet of the Week
Best Bet: Jacksonville Jaguars -10.5 over Tennessee Titans
Jacksonville enters Week 10 with a 6-2 record and a league-leading plus-nine turnover differential. The Jaguars have defeated Indianapolis 42-7 and Baltimore 33-10 in their last two games, covering large spreads in both victories.
Tennessee is 1-7, winless at home, and coming out of its bye after moving safety Amani Hooker and defensive tackle Jeffery Simmons. Jacksonville went in the opposite direction, adding Jessie Bates III, Jordan Davis, and Davon Godchaux to a defense allowing only 15.1 points per game.
The double-digit spread introduces some risk, but Jacksonville owns major advantages at quarterback, on third down, in the red zone, and in turnover production. The Jaguars have also won four consecutive meetings with Tennessee.
Predicted Score: Jaguars 31, Titans 13
Washington Commanders at New York Giants
Washington is 2-5-1 following a 20-13 loss to the Rams. The Commanders have yet to win on the road and have scored 20 points or fewer in three of their last five games. That creates a difficult situation against a Giants defense that has helped New York win two straight.
The Giants are 5-2-1 after holding Philadelphia to 11 points. These teams tied 27-27 in their first meeting, but New York has played better football since that game and owns the more dependable defense. The Giants should generate enough pressure to control the rematch.
Predicted Score: Giants 23, Commanders 17
Picks: Giants moneyline, Giants -2.5, and under 41.5
New England Patriots vs. Detroit Lions
New England and Detroit meet in Munich on Sunday morning. The Patriots are 5-4 after allowing 45 points against Green Bay, while Detroit is 6-2 and has won four consecutive games.
The Lions have scored 222 points through eight games and should be able to attack a New England defense that struggled against the Packers. The international setting makes laying points slightly less comfortable, but Detroit has the stronger offensive line and more explosive offense.
Predicted Score: Lions 28, Patriots 24
Picks: Lions moneyline, Lions -2.5, and over 51
Kansas City Chiefs at Atlanta Falcons
Kansas City improved to 6-2 by defeating the Jets 35-12. The Chiefs also added another receiving option at the trade deadline, giving Patrick Mahomes additional help for the second half of the season.
Atlanta is 3-6 after allowing Cincinnati to score 34 points in Madrid. The Falcons have lost two straight and will now face another top AFC quarterback. Kansas City’s defense should prevent Atlanta from matching Mahomes for four quarters.
Predicted Score: Chiefs 27, Falcons 20
Picks: Chiefs moneyline, Chiefs -3.5, and over 45.5
Houston Texans at Cleveland Browns
Houston produced its best offensive performance of the season in a 44-22 victory over the Chargers. The Texans are only 3-5, but all three of their wins have come on the road.
Cleveland fell to 5-4 following a 23-22 overtime loss in New Orleans. The Browns are 3-0 at home, so Houston should not expect another easy offensive afternoon. The Texans still have the defensive advantage and should force Cleveland to operate through long drives.
Predicted Score: Texans 23, Browns 16
Picks: Texans moneyline, Texans -5, and under 40
Minnesota Vikings at Green Bay Packers
Minnesota has dropped two consecutive games after beginning the season 6-0. The Vikings managed only six points against Buffalo and now travel to Lambeau Field for an important NFC North matchup.
Green Bay has won two straight and scored 45 points against New England in Week 9. The Packers have been more productive offensively, and their home-field advantage matters in a divisional game between teams competing near the top of the conference.
Predicted Score: Packers 24, Vikings 20
Picks: Packers moneyline, Packers -3.5, and over 42
Miami Dolphins at Indianapolis Colts
Miami is 1-7 after managing only nine points against Detroit. The Dolphins have scored 126 points this season and continue to struggle when opponents take away their limited explosive-play opportunities.
Indianapolis has lost five straight, but the Colts were competitive in a 27-23 loss to Dallas. Neither offense deserves much trust, making the low total understandable. Indianapolis should benefit from playing at home against a Miami team that has scored 16 points or fewer in five games.
Predicted Score: Colts 21, Dolphins 16
Picks: Colts moneyline, Colts -3.5, and under 38.5
Carolina Panthers at New Orleans Saints
Carolina is 3-5 following a 26-21 loss to Denver. The Panthers showed some offensive improvement in that game, but they have lost three straight and remain inconsistent defensively.
New Orleans earned a 23-22 overtime victory over Cleveland. The Saints are only 1-4 at home, but their offense has scored at least 23 points in three of its last four games. A close divisional matchup should produce enough fourth-quarter scoring to push the total over.
Predicted Score: Saints 27, Panthers 23
Picks: Saints moneyline, Saints -2.5, and over 48.5
Buffalo Bills at New York Jets
Buffalo improved to 7-1 by holding Minnesota to six points. The Bills have won four straight and added safety Amani Hooker to an already productive defense at the trade deadline.
The Jets are 2-7 after losing 35-12 in Kansas City. New York has dropped four consecutive games and traded safety Andre Cisco to Detroit. Buffalo should control possession and create short fields, although the elevated total makes the under more attractive than expected.
Predicted Score: Bills 31, Jets 17
Picks: Bills moneyline, Bills -8, and under 51
Jacksonville Jaguars at Tennessee Titans
Jacksonville has won two straight by a combined 58 points. Trevor Lawrence has thrown 18 touchdowns against only four interceptions, and the Jaguars lead the NFL with a plus-nine turnover differential.
Tennessee is 1-7 and has not won at Nissan Stadium. The Titans had additional preparation time during their bye, but their offense ranks near the bottom of the league in scoring, yardage, and time of possession. The trade-deadline departures of Simmons and Hooker further weaken a defense preparing to face one of the AFC’s best offenses.
Predicted Score: Jaguars 31, Titans 13
Picks: Jaguars moneyline, Jaguars -10.5, and under 46.5
Los Angeles Rams at Arizona Cardinals
The Rams have won three straight after beating Washington 20-13. Los Angeles is allowing just over 20 points per game and now faces an Arizona offense that produced only three points in Seattle.
Arizona is 3-6 and winless at home. The Cardinals also traded quarterback Jacoby Brissett and wide receiver Marvin Harrison Jr., leaving additional questions around an offense that was already struggling. Los Angeles should control this game with its defense.
Predicted Score: Rams 27, Cardinals 10
Picks: Rams moneyline, Rams -9, and under 39.5
Seattle Seahawks at Las Vegas Raiders
Seattle held Arizona to three points in Week 9 and has allowed only 162 points through nine games. The Seahawks have been inconsistent on the road, but their defense has a favorable matchup against a changing Las Vegas offense.
The Raiders traded Kirk Cousins to Minnesota after falling 38-17 against San Francisco. Las Vegas has surrendered 268 points and has only one home victory. Seattle should create pressure, force turnovers, and eventually pull away.
Predicted Score: Seahawks 27, Raiders 17
Picks: Seahawks moneyline, Seahawks -6.5, and over 40.5
San Francisco 49ers at Dallas Cowboys
San Francisco is 7-1 and has scored 235 points. The 49ers strengthened their offense at the deadline and now face a Dallas defense allowing more than 26 points per game.
Dallas improved to 4-5 with a 27-23 victory over Indianapolis. The Cowboys have enough passing talent to contribute to a shootout, but San Francisco is the more efficient team in the red zone and on third down. The 49ers should separate late in the game.
Predicted Score: 49ers 34, Cowboys 27
Picks: 49ers moneyline, 49ers -4, and over 55.5
Pittsburgh Steelers at Cincinnati Bengals
Pittsburgh returns from its bye with a 6-2 record and four consecutive victories. The Steelers have allowed only 144 points, but they now face a Cincinnati offense averaging 30 points per game.
The Bengals are also 6-2 and have won four straight. Joe Burrow and Ja’Marr Chase overwhelmed Atlanta in Madrid, and Cincinnati owns the league’s most efficient passing offense. Pittsburgh can keep the game close, but the Bengals have the higher scoring ceiling at home.
Predicted Score: Bengals 28, Steelers 24
Picks: Bengals moneyline, Bengals -3.5, and over 49.5
Los Angeles Chargers at Baltimore Ravens
The Chargers are the NFL’s only winless team after surrendering 44 points to Houston. Los Angeles has been outscored by 98 points and has failed to score more than 22 points in any game.
Baltimore has lost four straight and remains unsettled at quarterback, but the Ravens have the better defense and home-field advantage. Newly acquired quarterback Jacoby Brissett gives Baltimore another experienced option if Lamar Jackson remains unavailable. The uncertainty surrounding both offenses supports the under.
Predicted Score: Ravens 23, Chargers 13
Picks: Ravens moneyline, Ravens -4.5, and under 38.5
Odds, injuries, weather conditions, and player availability were reviewed on November 10, 2026, and may change before kickoff.
NFL Picks Record Regular Season
| Category | Record |
|---|---|
| Overall NFL Picks | 190-172-1 |
| Moneyline Picks | 87-57 |
| ATS Picks | 61-74-1 |
| Total Picks | 73-63 |
| Best Bets | 3-6 |
The regular-season record begins at 0-0 and will be updated after the completion of Week 1.
NFL Preseason Picks Record
| Category | Record |
|---|---|
| Overall NFL Picks | 32-18-1 |
| Moneyline Picks | 9-8-0 |
| ATS Picks | 8-8-1 |
| Total Picks | 15-2-0 |
| Best Bets | 0-2 |
The record will begin with the 2026 NFL preseason and will be updated after each completed slate.It will be updated to regular season picks only after the preseason is completed.
How to Bet on NFL Games
The three most popular NFL betting markets are the moneyline, point spread, and game total. Each market provides a different way to wager on a game depending on where you believe the best betting value exists.
A moneyline wager is a bet on which team will win the game outright. The final margin does not matter. Favorites normally come with a higher price, while an underdog moneyline offers a larger potential return.
ATS stands for “against the spread.” The favorite must win by more than the listed point spread to cover, while the underdog can cover by winning outright or losing by fewer points than the spread. If the final margin lands directly on the listed number, the wager is normally graded as a push.
A total wager focuses on the combined number of points scored by both teams. Bettors can select the over if they expect the teams to combine for more points than the posted total or the under if they anticipate a lower-scoring contest.
What We Consider When Making NFL Picks
Our NFL picks are focused on identifying betting value rather than simply selecting the most recognizable team or obvious favorite. We evaluate quarterback play, offensive and defensive efficiency, recent performance, turnover margin, injuries, home-field advantage, scheduling situations, coaching tendencies, weather conditions, and how sportsbooks are pricing each matchup.
During the preseason, we place additional importance on quarterback rotations, projected playing time, roster depth, coaching approach, and the number of established starters expected to participate. Preseason results are less predictable because winning the game is not always a team’s primary objective.
The process changes during the playoffs, when teams shorten their rotations and every possession carries greater importance. Regardless of the point in the season, the goal remains the same: finding a wager where the available odds may not fully reflect the most likely outcome.
NFL Betting Tips
Shopping for the best available line is one of the simplest ways to improve your long-term NFL betting results. A half-point difference may not appear significant, but it can determine whether a point-spread or total wager wins, loses, or pushes.
It is also important to distinguish between predicting a winner and identifying betting value. A team may be likely to win without offering value at its current moneyline or point spread. Likewise, an underdog can be a worthwhile wager even when it is not expected to win outright.
Remain disciplined with your wager sizes and avoid dramatically increasing your stakes after a loss. Successful sports betting is based on making consistent decisions over an entire season rather than trying to win every wager.
NFL Preseason Betting
NFL preseason games require a different approach from regular-season contests. Star players may appear for only a few drives or remain on the sideline for the entire game. Backup quarterbacks, rookies, and players competing for roster spots can determine the final result.
Coaches also have different preseason priorities. Some place greater emphasis on winning, while others focus almost exclusively on player evaluation and installing their systems. Projected quarterback rotations and roster depth can therefore be more useful than a team’s previous regular-season record.
Betting lines may move quickly when information about playing time becomes public. Waiting for reliable reports can provide valuable information, although it may also mean accepting a less favourable number.
NFL Regular-Season Betting
Regular-season NFL betting offers more dependable information about team strength, personnel, coaching tendencies, and player roles. However, bettors should avoid reacting too strongly to one result, particularly during the opening weeks.
Matchups are often more important than overall records. A strong team may encounter difficulties against an opponent whose defensive scheme or offensive style exposes a specific weakness. Travel, rest, weather, injuries, and changes along the offensive line can also influence the betting value.
Because NFL point spreads and totals move throughout the week, the number attached to a wager is just as important as the team being selected.
NFL Playoff Betting
The NFL playoffs feature stronger competition and increased public betting interest. Sportsbooks have extensive information about every remaining team, which can make obvious value more difficult to find.
Home-field advantage, quarterback experience, defensive pressure, weather, and late-game execution become particularly important during elimination games. Bettors should also consider how each team’s style matches up against its opponent rather than relying solely on its regular-season record.
The Super Bowl presents an additional challenge because of the two-week break, neutral venue, increased media attention, and expanded selection of betting markets.
Responsible Gambling Reminder
Sports betting should always be treated as entertainment rather than guaranteed income. Only wager what you can comfortably afford to lose, establish reasonable limits, and never chase losses.
If betting stops being enjoyable or begins causing financial or emotional stress, take a break and seek assistance. Responsible gambling is more important than the outcome of any individual wager.
NFL Picks FAQ
Are these NFL picks updated every week?
Yes. We update this page throughout the NFL preseason, regular season, and playoffs with moneyline picks, ATS picks, total picks, and our best bet.
Do you provide picks for every NFL game?
Yes. Whenever a complete NFL slate is available, we aim to provide picks and analysis for every scheduled game.
What is the best NFL bet this week?
Our favourite wager is featured in the NFL Best Bet of the Week section near the top of the page. The selection may be a moneyline, point spread, total, or another widely available betting market.
Do you track your NFL betting record?
Yes. We maintain running records for our overall NFL picks, moneyline selections, ATS picks, totals, and best bets.
What does ATS mean in NFL betting?
ATS stands for “against the spread.” Instead of merely selecting the winner, you are wagering on whether a team will cover the point spread established by the sportsbook.
What does NFL moneyline mean?
An NFL moneyline wager is a bet on which team will win the game outright. The winning margin does not matter, but favourites and underdogs are offered at different prices.
What is an NFL total?
The total is the projected number of combined points for both teams. Bettors can wager on whether the final combined score will finish over or under that number.
Do you provide NFL preseason picks?
Yes. Our NFL coverage begins with the preseason and continues through the Super Bowl. Because preseason playing time can be unpredictable, we wait for reliable quarterback rotation and personnel information whenever possible.
When should I place an NFL bet?
That depends on the market. Betting early may help you secure a favourable line, while waiting can provide more information about injuries, weather, and projected player availability. Always compare the latest odds before placing a wager.
What is the best way to bet on NFL games?
Most NFL bettors focus on moneylines, point spreads, and totals. The key is identifying value, comparing odds, managing your bankroll, and remaining disciplined throughout the season.
More Free Football Picks
Are you looking for more predictions? Check out our free football picks covering the biggest games from across the sport.
Interested in Canadian football? Visit our free CFL picks for weekly moneyline, ATS, total, and best-bet predictions.
College football more your jam? Check out our free college football picks throughout the regular season, conference championships, and bowl schedule.
If you want to keep up with the latest news and trade rumors then check out the NFL website.
