Date: Saturday, August 16, 2025
Time: 1:00 PM ET
Location: Lucas Oil Stadium, Indianapolis, IN
TV: —
The Green Bay Packers head to Indianapolis to face the Colts in a preseason matchup where both sides will be evaluating depth and fine-tuning rotations. Green Bay’s offense showed promise in their opener, while Indianapolis displayed strong defensive pressure but will look for better consistency from their quarterbacks.
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Matchup Overview
Indianapolis enters as a 6-point home favorite with the total set at 40.5. The Colts are expected to give Gardner Minshew limited snaps before turning things over to Anthony Richardson’s backups, while Green Bay will likely rotate Sean Clifford and rookie Michael Pratt heavily after Jordan Love’s brief opening series.
Green Bay Packers
Offensively, the Packers looked balanced in Week 1, mixing quick passing with effective runs from backup RB Emanuel Wilson. Clifford showed command of the offense, hitting timing routes and moving the chains against second-team defenses. On defense, Green Bay created turnovers and held firm in the red zone but will need to tighten coverage on deep shots. Special teams were efficient, highlighted by solid punt returns that flipped field position. The Packers are 4-2 ATS in their last six preseason contests.
Indianapolis Colts
The Colts’ offense found mixed success in their preseason opener, with Gardner Minshew leading a scoring drive before giving way to Sam Ehlinger. The run game looked solid behind rookie RB Evan Hull, but pass protection was inconsistent once starters left the field. Defensively, Indianapolis pressured the quarterback throughout, recording multiple sacks, but they were vulnerable to screens and checkdowns. Special teams contributed with a long punt return that set up a short scoring drive. The Colts have gone Over the total in five of their last seven preseason games at home.
Key Matchups to Watch
- Packers Backup QB Play vs. Colts Secondary – Clifford and Pratt will need to attack smartly to avoid turnovers.
- Colts Pass Rush vs. Packers O-Line Depth – Can Green Bay’s reserves hold up in protection?
- Red Zone Efficiency – Both teams stalled at times last week; finishing drives will be critical.
Betting Odds
- Spread: Colts -6 / Packers +6
- Total (O/U): 40.5
- Moneyline: Colts -250 / Packers +205
(Odds via ESPN BET at time of writing — subject to change)
Prediction
The Colts’ defensive front should control the line of scrimmage, but Green Bay’s offensive depth at QB and RB could keep them within striking distance. Expect a competitive game early with Indianapolis pulling away late thanks to their defensive pressure and home-field edge.
Projected Final Score:
Colts 24 – Packers 17
- Total Points: 41 → ✅ Over 40.5
- Margin: 7 points → ✅ Colts cover -6
Best Bets
- Colts -6 (-110) – Indy’s defensive front can disrupt Green Bay’s rhythm.
- Over 40.5 (-110) – Both teams have backup QBs capable of moving the ball.
- First Half Colts -3 (-110) – Expect Indianapolis to build an early lead at home.
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